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Simona Collina completed graduation cum laude in Medicinal Chemistry and Pharmaceutical Technology in 1989, from University of Pavia, Italy. In December 1989 - January 1992, was researcher at the laboratory “Analytical researches” of SPA (Società Prodotti Antibiotici) Milan. From 1992-2001, was assistant professor (SSD CHIM/08), Faculty of Pharmacy, University of Pavia 2001-ongoing, Associate Professor SSD CHIM/08 Department of drug Sciences, University of Pavia 2017 National Habilitation for Full Professor of Medicinal Chemistry (CHIM/08) – Italian Ministry of Research and University.


Sigma Receptors (SRs) represent an interesting orphan class of molecular targets to hit for counteracting neurodegenerative diseases and cancer. They can be divided into two receptor subtypes (S1R and S2R, respectively), endowed with different physio-pathological and structural properties. From a therapeutic standpoint, the pharmacological activity of S1Rs is strictly related to the modulators that they interact with. In detail, S1R agonists promote neuroprotection and neuroplasticity, whereas antagonists can be beneficial in thwarting neuropathic pain and tumorous manifestations. Conversely, S2R modulators may have a pivotal role as anticancer agents. So far, four compounds reached the Clinical Stage of the Drug Discovery Process, as drug candidate in therapy and diagnosis for Alzheimer’s disease (ANAVEX 2-73, AVP-923), for neuropathic pain (MR309) and cancer ([18F]-ISO-1). The Medicinal Chemistry Laboratory (MedChemLab) is part of this scenario and has a long lasting experience in this field. Indeed, the group spent its efforts in designing and synthetizing molecules with affinity and selectivity towards SRs and discoved (R)-RC-33 and RC-106 as promising compounds. (R)-RC-33 is a S1R agonist compound, characterized by good S1R affinity, good in vivo pharmacokinetic profile and endowed with neuroprotective properties. RC-106 is a pan-SR ligand (S1R antagonist and S2R agonist) showing anticancer activity towards a panel of cancer cell lines. These encouraging results lead members of the MedChemLab group to keep believing that SR modulators could become a relevant opportunity in the pharmaceutical field. Accordingly, throughout this speech the state-of-art and new insights of SRs, as well as the MedChemLab projects will be depicted.

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Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.


Registration fees do not include insurance of any kind.


Please note that any (or) all transportation and parking is the responsibility of the registrant.


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All cancellations or modifications of registration must be made in writing to Program Manager(

Cancellation Policy

If Allied academies cancel this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Conferences (AAC) event which must occur within one year from the date of cancellation.


If Allied academies postpone an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Conferences event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization if registered person is unable to attend the event. Transfers must be made by the registered person in writing to Program ManagerDetails must be included with the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

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Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits

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